XP64 & Vista 64 are both fully working with TB. I use both with no issues.
(Windows 7 has issues related to GFX drivers & Piss-poor GL support)

So lets find out what the exact problem is you're having.

Go into your Control Panel, then Administrative Tools, then Event Viewer.

Open Windows Logs, then select Application.

Look in the list for TB.EXE crashing & post the reason it gives here. It'll be easy to spot, there'll either be a ! or X icon where it falls over.